Malignancy involving the mesothelial cells of the human body, including the pleura, peritoneum, pericardium, and testis, known as mesothelioma malignant, either local or diffuse. Most, but not all, cases malignant mesothelioma (malignant mesothelioma) in the pleural (lung cancer lung) is usually associated with exposure to asbestos. Patients with pleural malignant mesothelioma, 77% had been exposed to asbestos in the past. Diagnosis of mesothelioma is difficult to enforce because the results from analysis of effusion fluids from cancer usually does not terdiagnostik. Mesothelioma is more common in men than women and it occurs most often in the fifth decade of age until the 7th decade. Most cases (about 90%) of malignant pleural mesothelioma occurs at.
From the picture there are 3 types of mesothelioma histologinya of sarcomatous mesothelioma , epithelial, and mixed (mixed). Pleural mesothelioma usually begins as plaques and nodules which combine to produce sheetlike neoplasm. The growth of the tumor usually begins in the lower chest. The tumor can invade the diaphragm and lung surface covered and the gap interlobaris.
peritoneum on the abdominal cavum image
When developing the disease, often spread to the lung parenchyma, chest wall and the wall of the mediastinum. Pleural mesothelioma can spread into the esophagus, ribs, spine, brachial plexus, and superior vena cava .
Asbestos , amphibole asbestos, asbestos-crocidolite, and amosite asbestos in particular, is a major carcinogen involved in the pathogenesis. Chrysotile asbestos exposure was associated with a lower incidence of mesothelioma. Industrial areas with the occurrence of frequent dikaitakan mesotelioma result of asbestos exposure include mining industry, ship building which involves the use of asbestos, asbestos cement manufacturing, ceramics, paper mill, auto parts, and repair factory train.
Clinical manifestations / symptoms that occurred in mesothelioma clinics are:
• Nonpleuritic dyspnea and pain in the chest wall is the most common symptoms that occur in malignant mesothelioma. (Approximately 60-90% of patients had symptoms of chest pain or dyspnea.)
• In patients with malignant mesothelioma, pleural effusion physical findings are usually known by percussion and auscultation.
• In rare cases, malignant mesothelioma manifests as cord compression, brachial plexopathy, Horner syndrome , or superior vena cava syndrome . Death is usually caused by infection or respiratory failure of the development of mesothelioma.
• The main areas that often occurs in the pleura (87%), peritoneum (5.1%), and pericardium (0.4%).
